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thermal melting of DNA
Thermal Melting od DNA

What is Tm ?

Guanine-rich sequences and G-quadruplex
Guanine-rich sequences
special motifs
Guanine-rich sequences and G-quadruplex
Guanine-rich sequences and G-quadruplex

Distinctive higher order geometry of Guanine-rich sequences and their structural, Chemical and Biological aspects as well as Oncological consequences have been discussed in details in my videos. Please watch, study and learn more.

Nucleic Acid mimics

All you need to know

about nucleic acid mimics

and related research

Free Online Tutorial in Structural Biology of Nucleic Acids
Free Online Tutorial in Structural Biology of Nucleic Acids
Free Online Tutorial in Structural Biology of Nucleic Acids

Origin of CD bands for nucleic acids:

3 determining factors:

  1. asymmetry of the sugar moity

  2. relative base-stacking geometry

  3. helical positioning of base-pairs

Free Online Tutorial in Structural Biology of Nucleic Acids

Circular Dichroism of G-quadruplex

What is the source of distinct CD spectra ?

​

2 determining factors:

​

  1. differential G-tetrad polarity

  2. differential folding geometry

​

Remember, "tetrad polarity" means "directional orientation", it does not refer to charge.

Free Online Tutorial in Structural Biology of Nucleic Acids

anti/anti G-tetrad

versus

syn/anti G-tetrad

Free Online Tutorial in Structural Biology of Nucleic Acids

stacking of G-quartets

head-to-head polarity

versus

head-to-tail polarity

This is how they look like on CD spectral analyses

Free Online Tutorial in Structural Biology of Nucleic Acids
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